Molecular Formula | C6H14N2O2.HCl |
Molar Mass | 182.65 |
Melting Point | 263-264℃ |
Boling Point | 311.5°C at 760 mmHg |
Specific Rotation(α) | 21 º (C=8, 6N HCL) |
Flash Point | 142.2°C |
Water Solubility | 65 g/100 mL (20℃) |
Solubility | Easily soluble in water, slightly soluble in ethanol and ether |
Vapor Presure | 0.000123mmHg at 25°C |
Appearance | Crystallization |
Storage Condition | 2-8℃ |
MDL | MFCD00064564 |
Use | Used as pharmaceutical raw materials and food, feed additives |
Risk Codes | 34 - Causes burns |
Safety Description | S24/25 - Avoid contact with skin and eyes. |
UN IDs | UN 1789 8/PG 3 |
Raw Materials | Ammonium sulfate Sucrose L-Glutamic acid L-Lysine Molasses L-Threonine L-ASPARTIC ACID L-Homoserine |
Downstream Products | L-Lysine hydrochloride |
Reference Show more | 1. [IF=9.229] Jianhua Lv et al."Antifouling and Antibacterial Properties Constructed by Quaternary Ammonium and Benzyl Ester Derived from Lysine Methacrylamide."Acs Appl Mater Inter. 2019;11(28):25556–25568 2. [IF=3.398] Hao Zhang et al."α-Glucosidase-Mediated Glucometer Readout for Portable Monitoring of Acarbose and Migliol."Chemosensors. 2022 Jun;10(6):198 |
white powder, no odor or slightly with specific odor. Soluble in water, insoluble in ethanol and ether. 1g of the product is soluble in 2.5ml of water, 10 ml of glycerol or looml of propylene glycol at 20 °c. Strong hygroscopicity. Relatively stable, but easy to agglomerate at high temperature, coloring. Stable under acidic conditions, alkaline conditions when reducing sugar is easy to decompose, and vitamin C or vitamin K3 coexistence when easy coloring.
Brevibacterium flavum or Corynebacterium glutamicum were used as production bacteria, and the product was obtained by fermentation.
This product is L-2, 6-diaminohexanoic acid hydrochloride. The content of C6H14N202 • HCl shall not be less than 98.5% calculated on a dry basis.
take this product, precision weighing, add 6mol / L hydrochloric acid solution to dissolve and quantitatively dilute to make a solution containing about 80mg per lml, and determine according to law (General 0621), the specific rotation was 20.4 ° to 21.5 °.
lysine is one of the essential amino acids and an excellent food fortifier. Used in drinks, rice, flour, canned food, can improve the utilization rate of protein, so as to greatly strengthen the nutrition of food, to promote growth and development, increase appetite, reduce disease, enhance the role of physical fitness, used in canned food, the role of deodorant preservation. China's provisions can be used for processing noodles flour, biscuits and bread, the use of 1~2g/kg.
take l.Og of this product, Add 10ml of water to dissolve, and measure it according to law (General rule 0631). The pH value should be 5.0~6.0.
take 0.5g of this product, add water 10ml to dissolve, according to UV-visible spectrophotometry (General rule 0401), measure the transmittance at 430nm wavelength, not less than 98.0%.
take l.Og of this product and check it according to law (General rule 0802). Compared with the control solution made of 0.02% of standard potassium sulfate solution, it should not be more concentrated ().
take 0.10g of this product and check it according to law (General rule 0808). Compared with the control solution made of 0.02% of standard chlorinated saddle solution, it shall not be deeper ().
take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 20mg per lml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute to scale with water, shake, as a control solution; Take the appropriate amount of lysine hydrochloride control and arginine control, and place in the same measuring flask, water was added to dissolve and diluted to prepare a solution containing about 0.4mg each per 1ml as a system-suitable solution. According to the thin layer chromatography (General 0502) test, absorb 5ul of each of the above three solutions, respectively point on the same silica gel G thin layer plate, with N-propanol-concentrated ammonia solution (2:1) as the developing solvent, expand, dry, spray with ninhydrin in acetone solution (1-50), heat at 80°C until spots appear, and examine immediately. The control solution should show a clear spot, and the system applicable solution should show two completely separated spots. If the test solution shows impurity spots, the color should not be deeper (0.5%) than the main spot of the control solution.
take this product, dry at 105°C for 3 hours, loss of weight shall not exceed 0.4% (General rule 0831).
not more than 0.1% (General rule 0841).
take 0.50g of this product and check it according to law (General rule 0807). Compared with the control solution made of 0.003% of standard iron solution, it should not be deeper ().
take 2.0g of this product, add 23ml of water to dissolve, add 2ml of acetate buffer (pH 3.5), and check according to law (General rule 0821 first law), containing heavy metals shall not exceed 10 parts per million.
take 2.0g of this product, add 23ml of water to dissolve, add 5ml of hydrochloric acid, check according to law (General rule 0822 first law), should comply with the provisions (0.0001%).
take this product, check according to law (General 1143), each lg of lysine hydrochloride containing endotoxin should be less than 10EU. (For injection)
take about 0.35g of this product, precision weighing, add 20ml of water to dissolve, add 2ml of dilute acetic acid and 8~10 drops of bromophenol blue indicator solution, and use silver nitrate titration solution (0.1 mol/ L) titration to blue-purple. Each 1 ml of silver nitrate titration solution (0.1 mol/L) corresponds to 3.545mg of C1. The chlorine content shall be 19.0%-19.6% based on the dry product.
take this product about 90mg, precision weighing, add anhydrous formic acid 3ml to dissolve, add glacial acetic acid 50ml and Mercury acetate test solution 10ml, according to the potential titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 9.133mg of C6H14N202. Hc1.
amino acid drugs.
light shielding, sealed storage.